Time integral of drug concentration in the central (plasma) compartment
โ Scribed by Wilfred J. Westlake
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 207 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
A problem of substantial delay in reaching the steady state drug concentration in particular organ (compartment) compared to the time of reaching the steady state plasma concentration is considered. It is shown that the ratio of the terminal (V(beta)) and the steady state (V(ss)) volumes of distribu
The concentration of drug in plasma may not necessarily be much less than that of the drug binding proteins, as often considered. Thus the unbound drug fraction could be concentration dependent, which should be taken into account in the interpretation of drug pharmacokinetics and modeling. It is sho
The article considers the problem of determination of organ clearance and the time course of drug plasma concentration using the model for which the drug transit time through the organ is regarded as one of the parameters. The suggested nonsteady state approach to the determination of organ clearanc