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Time-dependent model for hemoglobin and allosteric enzymes. I. General formulation

✍ Scribed by Robert Ter Bush; Colin J. Thompson

Publisher
Wiley (John Wiley & Sons)
Year
1971
Tongue
English
Weight
472 KB
Volume
10
Category
Article
ISSN
0006-3525

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✦ Synopsis

Synopsis

A previous equilibrium model is generalized to study time-depeiident behavior of hernoglobin aiid allosteric enzymes. An exact solution for two interacting subunits (e.g., diheme) is given, and a general method for solving the resulting set of difiereritial equations is outlined. At half saturation (equilibrium) concentration, the model takes a particularly simple form which suggests an experiment to determine the number of subunits of an allosteric enzyme, or in particular to distitiguish diheme from ordinary hemoglobin. The relation between the present model and other kiiietic models is also discussed.

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