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Time-dependent inhibition of γ-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine

✍ Scribed by Eric S. Lightcap; Mark Hans Hopkins; Gregory T. Olson; Richard B. Silverman


Book ID
103992118
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
528 KB
Volume
3
Category
Article
ISSN
0968-0896

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Inactivation of γ-aminobutyric acid amin
✍ Richard B. Silverman; Gregory T. Olson 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 652 KB

The mechanism of inactivation of gamma-aminobutyric acid aminotransferase (GABA-AT) by L-3-chloroalanine hydroxamate (1) was investigated. Inactivation of [3H]PLP-reconstituted GABA-AT with 1 followed by denaturation gave no PMP or enamine adduct to the PLP; however, a new unknown metabolite was obs