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Slow-Binding Inhibition of γ-Aminobutyric Acid Aminotransferase by Hydrazine Analogues †,‡

✍ Scribed by Lightcap, Eric S.; Silverman, Richard B.


Book ID
121450560
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
337 KB
Volume
39
Category
Article
ISSN
0022-2623

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The mechanism of inactivation of gamma-aminobutyric acid aminotransferase (GABA-AT) by L-3-chloroalanine hydroxamate (1) was investigated. Inactivation of [3H]PLP-reconstituted GABA-AT with 1 followed by denaturation gave no PMP or enamine adduct to the PLP; however, a new unknown metabolite was obs