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Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants

✍ Scribed by Thomas M. Polasek; John O. Miners

Book ID
108641907
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
867 KB
Volume
65
Category
Article
ISSN
0306-5251

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The magnitude of drugΒ±drug interactions in vitro involving competitive inhibition of cytochrome (CYP) isozymes by newer antidepressants can theoretically be shown to be dependent upon several factors. These include the concentration of both the substrate and inhibitor, the anity of the inhibitor for