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Drug metabolism by Escherichia coli expressing human cytochromes P450

✍ Scribed by Parikh, Asit; Gillam, Elizabeth M.J.; Guengerich, F. Peter


Book ID
109907157
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
655 KB
Volume
15
Category
Article
ISSN
1087-0156

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## Objectives: The biotransformation of caffeine has been studied in vitro using human cytochrome p-450 isoenzymes (cyps) expressed in human b-lymphoblastoid cell lines, namely cyp1a1, 1a2, 2a6, 2b6, 2d6-val, 2e1 and 3a4, and microsomal epoxide hydroxylase (eh). in addition, cyp2d6-met was also stu