✦ LIBER ✦

Time-dependent Closed Form Solutions for Fully Competitive Enzyme Reactions

✍ Scribed by S. Schnell; C. Mendoza

Publisher: Springer
Year: 2000
Tongue: English
Weight: 149 KB
Volume: 62
Category: Article
ISSN: 1522-9602
DOI: 10.1006/bulm.1999.0156

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✦ Synopsis

An analytic formalism developed earlier to describe the time evolution of the basic enzyme reaction is extended to fully competitive systems. Time-dependent closed form solutions are derived for the three nominal cases of competition: even, slow and fast inhibitors, allowing for the first time the complete characterization of the reactions. In agreement with previous work, the time-independent Michaelis-Menten approach is shown to be inaccurate when a fast inhibitor is present. The validity of the quasi-steady-state approximation on which the present framework is based is also revised.

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