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Closed Form Solution for Time-dependent Enzyme Kinetics

โœ Scribed by S. Schnell; C. Mendoza


Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
189 KB
Volume
187
Category
Article
ISSN
0022-5193

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โœฆ Synopsis


Based on the quasi-steady-state approximation, a closed form solution for the total time evolution of the reactant concentrations in the basic enzyme-substrate reaction is reported for the first time. Such a solution is given in terms of the omega function, which satisfies the transcendental equation W(x)exp(W(x)) = x, and enables the generation of the corresponding time derivatives thus fully characterizing the system. The agreement with results obtained from both the inner (fast region) and outer (slow region) solutions of singular perturbation procedures is very good, but an advantage of the present formalism is the analytic representation of the transition where the perturbation methods are shown to be inaccurate.


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