Time-Dependent Absorption of Phenprobamate Following Multiple Dosing in Rats
β Scribed by Jim Xin-Sheng Sun; Koral Embil; Ching-San C. Lee
- Book ID
- 114421134
- Publisher
- Springer US
- Year
- 1988
- Tongue
- English
- Weight
- 642 KB
- Volume
- 05
- Category
- Article
- ISSN
- 0724-8741
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The oral absorption of cyclosporin A (CyA) was studied in rats after 6, 12, 18, and 23 mg kg-' doses were given in an olive oil solution to determine if CyA absorption from the gastrointestinal tract was dose-dependent. Using serial blood samples obtained at various times after the respective doses,
The pharmacokinetics of cyclosporin A (CyA) were investigated in the rat following intravenous doses of 1.7, 3 . 3 , and 6-4mg kg-' and oral doses of 3.1, 6.8, and 12.9 mg kg-I . The blood concentration-time profile after intravenous administration was adequately described by a twocompartment model