Dosing time-dependent variation of bone resorption by cyclosporin A in rats’ femurs
✍ Scribed by Shuichi Tsuruoka; Tae Kaneda; Akimitsu Maeda; Takashi Ioka; Akio Fujimura
- Book ID
- 113586787
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 264 KB
- Volume
- 564
- Category
- Article
- ISSN
- 0014-2999
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📜 SIMILAR VOLUMES
The oral absorption of cyclosporin A (CyA) was studied in rats after 6, 12, 18, and 23 mg kg-' doses were given in an olive oil solution to determine if CyA absorption from the gastrointestinal tract was dose-dependent. Using serial blood samples obtained at various times after the respective doses,
The pharmacokinetics of cyclosporin A (CyA) were investigated in the rat following intravenous doses of 1.7, 3 . 3 , and 6-4mg kg-' and oral doses of 3.1, 6.8, and 12.9 mg kg-I . The blood concentration-time profile after intravenous administration was adequately described by a twocompartment model