## Abstract Amyotrophic lateral sclerosis (ALS) is associated with increased numbers of microglia within the central nervous system (CNS). However, it is unknown whether the microgliosis results from proliferation of CNS resident microglia, or recruitment of bone marrow (BM)βderived microglial prec
Time course and nature of brain atrophy in the MRL mouse model of central nervous system lupus
β Scribed by John G. Sled; Shoshana Spring; Matthijs van Eede; Jason P. Lerch; Sangeeta Ullal; Boris Sakic
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 324 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0004-3591
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Amyotrophic lateral sclerosis (ALS) is associated with increased numbers of microglia within the CNS. However, it is unclear to what extent bone marrow (BM)-derived cells contribute to this microgliosis. We have studied the adoptive transfer of green fluorescent protein (GFP)-labeled whole BM cells