TiCl4/Bu3N/(catalytic TMSOTf): Efficient agent for direct aldol addition and Claisen condensation

✍ Scribed by Yoshihiro Yoshida; Ryosuke Hayashi; Hiromasa Sumihara; Yoo Tanabe

• Book ID: 104258352
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 231 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)10320-3

✦ Synopsis

TiCI4/Bu3N conducts highly efficient cross aldol additions between different ketones and between ketones and aldehydes, in good to excellent yields with high synstereoselectivities. As an extension, direct Claisen condensation between methyl esters was also promoted by TiCI4/Bu3N with 0.05 equiv of TMSOTf co-catalyst.