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Catalytic TMSCl promoted powerful aldol addition and Claisen condensation mediated by TiCl4/Bu3N agent: comparison and evaluation with the Mukaiyama aldol addition

โœ Scribed by Yoshihiro Yoshida; Noriaki Matsumoto; Ryota Hamasaki; Yoo Tanabe


Book ID
104261465
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
263 KB
Volume
40
Category
Article
ISSN
0040-4039

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TiCl4/Bu3N/(catalytic TMSOTf): Efficient
โœ Yoshihiro Yoshida; Ryosuke Hayashi; Hiromasa Sumihara; Yoo Tanabe ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 231 KB

TiCI4/Bu3N conducts highly efficient cross aldol additions between different ketones and between ketones and aldehydes, in good to excellent yields with high synstereoselectivities. As an extension, direct Claisen condensation between methyl esters was also promoted by TiCI4/Bu3N with 0.05 equiv of