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Thyrotropin-releasing hormone and its receptor in glia

✍ Scribed by Teresa Fernández-Agulló

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
797 KB
Volume
33
Category
Article
ISSN
0894-1491

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✦ Synopsis

The presence of thyrotropin-releasing hormone (Thyroliberin, TRH) and its receptor (TRH-R) in frozen coronal sections of the adult rat spinal cord and neonatal rat astroglial cultures was investigated by means of immunocytochemistry and Western blot using polyclonal antibodies generated against the hormone and monoclonal antibodies originated against discrete sequences of the type 1 rat TRH receptor (TRH-R1). TRH-R1 and TRH are present both in astroglial cells from adult rats and in cultured cells from newborn animals. The localization of TRH and TRH-R1 in nonneuronal cells in the central nervous system may reflect that some of the neurotrophic actions of TRH upon the central nervous system are mediated by glial cells.

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Thyrotropin releasing hormone (TRH) has been reported to reduce stress-and deprivation-induced eating, hypothetically by induction of satiation. Early work demonstrated thyroid extracts reduced alcohol intake, and recent research shows a TRH analog specifically inhibits alcohol preference. We determ