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Thyroid function in pediatric patients after neck irradiation for Hodgkin disease

✍ Scribed by Green, Daniel M. ;Brecher, Martin L. ;Yakar, Daniel ;Blumenson, Leslie E. ;Lindsay, Alan N. ;Voorhess, Mary L. ;MacGillivray, Margaret ;Freeman, Arnold I.

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 523 KB
Volume: 8
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950080205

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✦ Synopsis

Abstract

Thyroid function was evaluated in a consecutively treated group of children and adolescents with Hodgkin disease who received incidental radiation to the thyroid gland. Ten of 27 (36.7%) were found to have elevated concentrations of thyroid‐stimulating hormone (TSH).

Two groups of patients had an increased incidence of thyroid dysfunction — those who had not had a pretreatment lymphangiogram and those who were less than 13 years of age at the time of neck irradiation. The estimated percentage of patients who did not have a pretreatment lymphangiogram who will develop TSH elevation was 67.7% and of patients who were 13 years of age or less when irradiated, 64.8%. Thyroid dysfunction developed in 6/7 patients who had both of these risk factors present.

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