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Gonadal function in pediatric patients following treatment for hodgkin disease

✍ Scribed by Green, Daniel M. ;Brecher, Martin L. ;Lindsay, Allan N. ;Yakar, Daniel ;Voorhess, Mary L. ;MacGillivray, Margaret H. ;Freeman, Arnold I.

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 581 KB
Volume: 9
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950090306

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Gonadal function was assessed by determination of the serum levels of follicle‐stimulating hormone (FSH) and luteinizing hormone (LH) in 24 children and adolescents 6—98 months after completion of treatment for Hodgkin disease that included pelvic irradiation and/or combination chemotherapy. Four of the five women and six of the nine men who received pelvic irradiation had elevations of serum FSH. Nine of these patients with an elevated FSH received combination chemotherapy in addition to pelvic irradiation. Five of seven males who received combination chemotherapy but no pelvic irradiation and were postpubertal at the time of evaluation had an elevated FSH level. Three of these five were prepubertal at the time of treatment. These results suggest that gonadal dysfunction occurred frequently among children and adolescents following treatment that included combination chemotherapy for Hodgkin disease.

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