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Thymidylate Synthase Activity in Normal and Malignant Gynecologic Tissues

✍ Scribed by Suzuki, M. ;Ohwada, M. ;Tamada, T.


Book ID
119844910
Publisher
Wiley (Blackwell Publishing)
Year
2010
Tongue
English
Weight
370 KB
Volume
18
Category
Article
ISSN
0389-2328

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Background. Head and neck squamous cell carcinomas (HNSCC) present variable aggressiveness and chemosensitivity. Because the glutathione (GSH) system and thymidylate synthase (TS) are involved in the resistance to the main drugs used in HNSCC (cisplatin and 5-FU), we studied these systems in tumors