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Thymidylate synthase activity, folates, and glutathione system in head and neck carcinoma and adjacent tissues

✍ Scribed by Dr. Orlando Parise Jr; Dr. François Janot; Dr. Bernard Luboinski; Dr. Liliane Massaad; Dr. Nicolas Albin; Dr. Caroline Toussaint; Dr. Marie-Ange Verjus; Dr. Marc Bonnay; Dr. Alain Gouyette; Dr. Guy G. Chabot

Book ID: 102848898
Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 617 KB
Volume: 16
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.2880160210

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✦ Synopsis

Background. Head and neck squamous cell carcinomas (HNSCC) present variable aggressiveness and chemosensitivity. Because the glutathione (GSH) system and thymidylate synthase (TS) are involved in the resistance to the main drugs used in HNSCC (cisplatin and 5-FU), we studied these systems in tumors and normal mucosae.

Methods. Tumor samples and normal adjacent mucosae were collected from 37 untreated HNSCC patients. GSH and glutathione S-transferase (GST) activity were assayed by spectrophotometry, whereas TS activity and folates were determined by radioassays.

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