Thymidylate synthase: A target for anticancer drug design
โ Scribed by K.R. Harrap; A.L. Jackman; D.R. Newell; G.A. Taylor; L.R. Hughes; A.H. Calvert
- Book ID
- 118372132
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 933 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0065-2571
No coin nor oath required. For personal study only.
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Thymidylate synthase (TS) is a very interesting target in antiproliferative diseases. Its inhibition causes thimineless death of the cells and compounds inhibiting TS are widely used in anticancer therapy. The classical antifolate TS inhibitors are structural analogs of the folate cofactor; they oft