✦ LIBER ✦

ChemInform Abstract: Thymidylate Synthase Inhibition: A Structure-Based Rationale for Drug Design

✍ Scribed by M. P. COSTI

Publisher: John Wiley and Sons
Year: 2010
Weight: 24 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199815286

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Thymidylate synthase inhibition: A struc

Thymidylate synthase inhibition: A structure-based rationale for drug design

✍ M. Paola Costi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB 👁 1 views

Thymidylate synthase (TS) is a very interesting target in antiproliferative diseases. Its inhibition causes thimineless death of the cells and compounds inhibiting TS are widely used in anticancer therapy. The classical antifolate TS inhibitors are structural analogs of the folate cofactor; they oft

ChemInform Abstract: RASSE: A New Method

ChemInform Abstract: RASSE: A New Method for Structure-Based Drug Design

✍ Z. LUO; R. WANG; L. LAI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 2 views

ChemInform Abstract: Structure-Based Des

ChemInform Abstract: Structure-Based Design of Substituted Diphenyl Sulfones and Sulfoxides as Lipophilic Inhibitors of Thymidylate Synthase.

✍ T. R. JONES; S. E. WEBBER; M. D. VARNEY; M. R. REDDY; K. K. LEWIS; V. KATHARDEKA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

ChemInform Abstract: Design and Synthesi

ChemInform Abstract: Design and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design.

✍ D. A. WALSH; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

ChemInform Abstract: Knowledge Based Pre

ChemInform Abstract: Knowledge Based Prediction of Ligand Binding Modes and Rational Inhibitor Design for Kinase Drug Discovery

✍ Arup K. Ghose; Torsten Herbertz; Douglas A. Pippin; Joseph M. Salvino; John P. M 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 24 KB

ChemInform Abstract: Active Site Pressur

ChemInform Abstract: Active Site Pressurization: A New Tool for Structure-Guided Drug Design and Other Studies of Protein Flexibility.

✍ Ian M. Withers; Michael P. Mazanetz; Hao Wang; Peter M. Fischer; Charles A. Laug 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 15 KB