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ChemInform Abstract: RASSE: A New Method for Structure-Based Drug Design

โœ Scribed by Z. LUO; R. WANG; L. LAI


Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
28
Category
Article
ISSN
0931-7597

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Thymidylate synthase inhibition: A struc
โœ M. Paola Costi ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 432 KB ๐Ÿ‘ 1 views

Thymidylate synthase (TS) is a very interesting target in antiproliferative diseases. Its inhibition causes thimineless death of the cells and compounds inhibiting TS are widely used in anticancer therapy. The classical antifolate TS inhibitors are structural analogs of the folate cofactor; they oft