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Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer

โœ Scribed by Hasenburg, Annette; Tong, Xiao-Wen; Rojas-Martinez, Augusto; Nyberg-Hoffman, Cassandra; Kieback, Christina C; Kaplan, Alan; Kaufman, Raymond H; Ramzy, Ibrahim; Aguilar-Cordova, Estuardo; Kieback, Dirk G


Book ID
110017722
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
126 KB
Volume
7
Category
Article
ISSN
0929-1903

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โœ Link, Charles J.; Levy, John P.; McCann, Leisa Z.; Moorman, Donald W. ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 74 KB ๐Ÿ‘ 2 views

## Background: The suicide gene and prodrug, herpes simplex thymidine kinase (hstk) and ganciclovir (gcv), are now in clinical trials for recurrent malignancies. ## Methods: We evaluated in vitro and in vivo efficacy of hstk gene transfer and gcv treatment of colonic adenocarcinoma in a syngeneic