Thymic Development and Selection of T Lymphocytes

✍ Scribed by Kensuke Takada, Izumi Ohigashi (auth.), Thomas Boehm, Yousuke Takahama (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2014
Tongue: English
Leaves: 134
Series: Current Topics in Microbiology and Immunology 373
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

✦ Table of Contents

Front Matter....Pages i-vii
Development and Function of Cortical Thymic Epithelial Cells....Pages 1-17
Mechanisms of Thymus Medulla Development and Function....Pages 19-47
Self-Peptides in TCR Repertoire Selection and Peripheral T Cell Function....Pages 49-67
Central Tolerance Induction....Pages 69-86
Trafficking to the Thymus....Pages 87-111
The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes....Pages 113-129
Back Matter....Pages 131-132

✦ Subjects

Immunology; Human Physiology; Cytogenetics

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