Epigenetic Regulation of Lymphocyte Development

✍ Scribed by Sven Heinz, Christopher K. Glass (auth.), Cornelis Murre (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2012
• Tongue: English
• Leaves: 202
• Series: Current Topics in Microbiology and Immunology 356
• Edition: 1
• Category: Library

✦ Synopsis

The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.

✦ Table of Contents

Front Matter....Pages i-x
Roles of Lineage-Determining Transcription Factors in Establishing Open Chromatin: Lessons From High-Throughput Studies....Pages 1-15
B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1....Pages 17-38
Epigenetic Features that Regulate IgH Locus Recombination and Expression....Pages 39-63
Local and Global Epigenetic Regulation of V(D)J Recombination....Pages 65-89
Genetic and Epigenetic Regulation of Tcrb Gene Assembly....Pages 91-116
T-Cell Identity and Epigenetic Memory....Pages 117-143
Encoding Stability Versus Flexibility: Lessons Learned From Examining Epigenetics in T Helper Cell Differentiation....Pages 145-164
The Epigenetic Landscape of Lineage Choice: Lessons From the Heritability of Cd4 and Cd8 Expression....Pages 165-188
Back Matter....Pages 189-191

✦ Subjects

Immunology; Gene Expression