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Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

โœ Scribed by Kawai, Tatsuo; Andrews, David; Colvin, Robert B.; Sachs, David H.; Cosimi, A. Benedict

Book ID
109827508
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
86 KB
Volume
6
Category
Article
ISSN
1078-8956

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โœ Kirk, Allan D.; Burkly, Linda C.; Batty, D. Scott; Baumgartner, Roxanne E.; Bern ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 688 KB

CD154 is the ligand for the receptor CD40. This ligand-receptor pair mediates endothelial and antigen-presenting cell activation, and facilitates the interaction of these cells with T cells and platelets. We demonstrate here that administration of a CD154-specific monoclonal antibody (hu5C8) allows