develop thrombocytopenia of various causes, e.g., decreased controls for the indirect and direct MAIPA assay, respectively, and production, increased turnover or splenic ''pooling.'' were obtained from healthy donors of blood group AB. The specificity of the antibodies was further determined by the
Thrombin generation in patients with cirrhosis: The role of platelets
β Scribed by Armando Tripodi; Massimo Primignani; Veena Chantarangkul; Marigrazia Clerici; Alessandra Dell'Era; Federica Fabris; Francesco Salerno; Pier Mannuccio Mannucci
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 285 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0270-9139
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ported as associated with liver cirrhosis. 4,5 Moreover, a vari-A defect in hemostasis has been repeatedly reported able degree of thrombopenia-caused mainly by an increased in patients with cirrhosis. However, the nature of this splenic pool of platelets-usually is present in cirrhotic padefect has
We studied the acute effects of ketanserin, a serotonin Sz antagonist, on systemic and splanchnic hemodynamics in 11 patients with cirrhosis. Mean arterial pressure decreased moderately but significantly after ketanserin. This effect was maximal at 6 min and correlated to the severity of cirrhosis.
The disposition of zomepirac was investigated in 18 patients with various liver diseases and in 10 healthy normal subjects in order to further test the hypothesis that glucuronidation of drugs may be spared in liver disease. Severity of the liver disease was assessed by the galactose elimination cap