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Target platelet antigens of autoantibodies in patients with primary biliary cirrhosis

✍ Scribed by S M Feistauer; E Penner; W R Mayr; S Panzer

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
134 KB
Volume
25
Category
Article
ISSN
0270-9139

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✦ Synopsis

develop thrombocytopenia of various causes, e.g., decreased controls for the indirect and direct MAIPA assay, respectively, and production, increased turnover or splenic ''pooling.'' were obtained from healthy donors of blood group AB.

The specificity of the antibodies was further determined by the production of eluates from platelets coated with antibodies. Eluates were either produced from the patients autologous platelets or after Abbreviations: PBC, primary biliary cirrhosis; PAIgG, platelet-associated IgG; GP, glycoin vitro coating of donor platelets incubated with patients sera, as protein; MAIPA, monoclonal antibody-specific immobilization of platelet. described previously. 7 In brief, platelets (ΓΊ10 8 ) were resuspended in From the

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