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Three New Indole Alkaloids from the Leaves of Kopsia officinalis

✍ Scribed by Hua Zhou; Hong-Ping He; Ning-Chuan Kong; Yue-Hu Wang; Xiang-Dong Liu; Xiao-Jiang Hao

Publisher
John Wiley and Sons
Year
2006
Tongue
German
Weight
86 KB
Volume
89
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Three new indole alkaloids, 11,12‐de(methylenedioxy)danuphylline (1), methyl (2__β__,11__β__,12__β__,19__α__)‐6,7‐didehydro‐8,21‐dioxo‐11,21‐cycloaspidospermidine‐2‐carboxylate (2), and (2__β__,5__β__)‐aspidofractinin‐16‐ol (3) were isolated from Kopsia officinalis, together with 16 known compounds. Their structures were determined by spectroscopic methods. The isolated known compound (−)‐12‐methoxykopsinaline displayed antimanic effects in Drosophila, with an IC~50~ value of 12.5 μg/ml.

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