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Three New Indole Alkaloids from the Leaves of Alstonia scholaris

✍ Scribed by Hua Zhou; Hong-Ping He; Xiao-Dong Luo; Yue-Hu Wang; Xian-Wen Yang; Ying-Tong Di; Xiao-Jiang Hao

Publisher
John Wiley and Sons
Year
2005
Tongue
German
Weight
81 KB
Volume
88
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Three new akuamillan‐type indole alkaloids, i.e., 5‐methoxystrictamine (=methyl (5__β__,16__R__,19__E__)‐5‐methoxyakuammilan‐17‐oate; 1), methyl (16__R__,19__E__)‐1,2‐dihydro‐16‐(hydroxymethyl)‐5‐oxoakuammilan‐17‐oate (2), and methyl (2__β__,16__R__,19__E__)‐4,5‐didehydro‐1,2‐dihydro‐2‐hydroxy‐16‐(hydroxymethyl)akuammilan‐4‐ium‐17‐oate chloride (3), have been isolated from the leaves of Alstonia scholaris, together with ten known compounds. Their structures were determined by spectroscopic means. None of the constituents showed significant cytotoxic activity towards WT cells.

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