Three-layered membranes of collagen/hydroxyapatite and chitosan for guided bone regeneration

✍ Scribed by Shu-Hua Teng; Eun-Jung Lee; Peng Wang; Du-Sik Shin; Hyoun-Ee Kim

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 186 KB
• Volume: 87B
• Category: Article
• ISSN: 1552-4973
• DOI: 10.1002/jbm.b.31082

✦ Synopsis

Abstract

The purpose of this study was to design a novel hybrid membrane with optimized properties for guided bone regeneration (GBR). Both the top and bottom layers of the sandwich‐structured membrane were composed of collagen containing 20 wt% hydroxyapatite (HA), while the middle layer was made of chitosan. The above three layers were formulated into an integral membrane from their respective slurries through a layer‐by‐layer filtration process. The phase and composition of the membrane were confirmed by FT‐IR and XRD analyses. The observation of its morphology by SEM showed that the membrane had a porous structure and structural integrity. The chitosan layer ensured the high tensile strength and elastic modulus of the membrane, while the presence of the collagen/HA composite layers endowed it with good flexibility and bioactivity. These results suggest that the integrated membrane prepared in this study would have the potential for use as a GBR material. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008