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Three-Dimensional Structure of RK-1: A Novel α-Defensin Peptide †

✍ Scribed by McManus, Ailsa M.; Dawson, Nicola F.; Wade, John D.; Carrington, Lyle E.; Winzor, Don J.; Craik, David J.


Book ID
121351954
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
453 KB
Volume
39
Category
Article
ISSN
0006-2960

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Chemical synthesis, characterization and
✍ Nicola F. Dawson; David J. Craik; Ailsa M. Mcmanus; Stuart G. Dashper; Eric C. R 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB

The 32-residue peptide, RK-1, a novel kidney-derived three disulfide-bonded member of the antimicrobial h-defensin family, was synthesized by the continuous flow Fmoc-solid phase method. The crude, cleaved and S-reduced linear peptide was both efficiently folded and oxidized in an acidic solution of