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The NMR Structure of Human β-Defensin-2 Reveals a Novel α-Helical Segment †,‡

✍ Scribed by Sawai, Monali V.; Jia, Hong Peng; Liu, Lide; Aseyev, Vladimir; Wiencek, John M.; McCray,, Paul B.; Ganz, Tomas; Kearney, William R.; Tack, Brian F.


Book ID
125896995
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
166 KB
Volume
40
Category
Article
ISSN
0006-2960

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## Abstract The 173–195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several ‘spots’ of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation‐prone conformations