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THREE-DIMENSIONAL RECONSTRUCTION OF BENIGN LYMPHOID AGGREGATES IN BONE MARROW TREPHINES

✍ Scribed by SALISBURY, JONATHAN R.; DEVERELL, MARK H.; COOKSON, M. JOHN

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
408 KB
Volume
178
Category
Article
ISSN
0022-3417

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✦ Synopsis

Distinguishing between deposits of low-grade non-Hodgkin's lymphoma and benign lymphoid aggregates in bone marrow trephine sections is a recognized problem in haematopathology. To test the hypothesis that benign lymphoid aggregates do not make contact with a trabecular surface, three-dimensional models were constructed of five serially sectioned bone marrow trephines, containing a total of 19 lymphoid aggregates known to be benign. The computer-generated images showed that benign lymphoid aggregates were located in the central marrow space and did not become paratrabecular. This suggests that a paratrabecular location may help in some cases to distinguish deposits of low-grade non-Hodgkin's lymphoma from benign lymphoid aggregates.

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