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Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance

✍ Scribed by Hong-Fang Lu; Kian-Ngiap Chua; Peng-Chi Zhang; Wei-Seng Lim; Seeram Ramakrishna; Kam W. Leong; Hai-Quan Mao

Book ID: 103999310
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 527 KB
Volume: 1
Category: Article
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2005.04.003

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## Abstract Bioartificial liver (BAL) devices have been developed to treat patients undergoing acute liver failure. One of the most important parameters to consider in designing these devices is the oxygen consumption rate of the seeded hepatocytes which are known to have oxygen consumption rates 1