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TGF-β1 regulation in hepatocyte-NIH3T3 co-culture is important for the enhanced hepatocyte function in 3D microenvironment

✍ Scribed by Ser-Mien Chia; Pao-Chun Lin; Hanry Yu


Book ID
102763850
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
847 KB
Volume
89
Category
Article
ISSN
0006-3592

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3D-microfluidic cell culture systems (3D-microFCCSs) support hepatocyte functions in vitro which can be further enhanced by controlled presentation of 100-200 pg/ml TGF-beta1, thus mimicking the roles of supporting cells in co-cultures. Controlled presentation of TGF-beta1 is achieved by either dire