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Three-Component Synthesis of Polysubstituted Benzene Derivatives via Diels—Alder Reaction of Cyclopentadienone Acetal with Alkyne.

✍ Scribed by Sota Sato; Hiroyuki Isobe; Takatsuga Tanaka; Tomohiko Ushijima; Eiichi Nakamura


Publisher
John Wiley and Sons
Year
2006
Weight
29 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract A hetero Diels‐Alder reaction with inverse electron demand between 4‐hydroxycoumarin, aromatic aldehydes and electron‐rich alkenes yielded a multitude of 2,4‐disubstituted 3,4‐dihydropyranocoumarins. This route opened an easy access to coumarin anticoagulants and provided a library of p