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Three component reactions of N-nucleophiles and activated acetylenes with NH-acids: A facile synthesis in water

✍ Scribed by Faramarz Rostami Charati; Zinatossadat Hossaini; Mohammad R. Hosseini-Tabatabaei

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
450 KB
Volume
49
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A straightforward and efficient method for the synthesis of 1,2‐dihydroisoquinolines via a one‐pot, three‐component reaction of isoquinoline, activated acetylenes, and NH‐acids in water at 70°C without using any catalyst is reported. The method offers several advantages including high yields of products and an easy workup procedure. J. Heterocyclic Chem., (2012).

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