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Three-Component Reactions Involving Zwitterionic Intermediates for the Construction of Heterocyclic Systems: One-Pot Synthesis of Highly Functionalized γ-Iminolactones.

✍ Scribed by Abbas Ali Esmaeili; Hamid Zendegani


Publisher
John Wiley and Sons
Year
2005
Weight
18 KB
Volume
36
Category
Article
ISSN
0931-7597

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Three-Component Reaction of an Isocyanid
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The zwitterion, formed from the reaction of an alkyl isocyanide and a dialkyl acetylenedicarboxylate, reacts with phenacyl halides in H 2 O to produce g-iminolactone derivatives in high yields. H 2 O helps to avoid the use of highly toxic and environmentally unfavorable solvents for this conversion.