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Three-Component Reaction of Isocyanides and 2-Formylbenzoic Acid with Dibenzylamine Catalyzed by Silica Nanoparticles under Solvent-Free Conditions

✍ Scribed by Ali Ramazani; Amir Mahyari

Book ID
102256586
Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
356 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2‐formylbenzoic acid and dibenzylamine in the presence of silica nanoparticles (silica NP, ca. 42 nm) proceeds smoothly at room temperature to afford isocoumarin (=1__H__‐2‐benzopyran‐1‐one) derivatives in high yields (Scheme 1 and Table 1).

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## Abstract magnified image A mild and stereoselective three‐component one‐step synthesis of __cis__‐isoquinolonic acid using silica sulfuric acid as a heterogeneous catalyst from an aldehyde, amine and homophthalic anhydride in acetonitrile is described. This new method produces pure products in