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Three-component one-pot synthesis of functionalised (Z)-4-benzylidene (and alkenylidene) pyrrolidines

✍ Scribed by Stéphane Azoulay; Nuno Monteiro; Geneviève Balme

Book ID
104252512
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
313 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A three-component synthesis of stereodefined 4-benzylidene-(or alkenylidene)-pyrrolidines from simple, readily available starting materials is described. This one-pot process is initiated by a conjugate addition of a propargylamine to a gem-diactivated olefin subsequently followed by a carbopalladation involving an aryl halide (or vinyl triflate).

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## Abstract magnified image A facile and rapid synthesis of the title compounds via one‐pot reaction of 2‐aminobenzonitrile, orthoesters and ammonium acetate under solvent‐free and microwave condition is described.