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Three-Component, One-Pot Reaction for the Combinatorial Synthesis of 1,3,4-Substituted Pyrazoles

✍ Scribed by Xie, Fuchun; Cheng, Gang; Hu, Youhong


Book ID
121319367
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
74 KB
Volume
8
Category
Article
ISSN
1520-4766

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The synthesis of 2-substituted azoles th
✍ Yijun Deng; Dennis J. Hlasta πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 87 KB

We have discovered a new reaction whereby 2-substituted azoles are formed in the reaction of an azolium ylide with reactive carbonyl compounds. These products contain a leaving group in the a-position, which on solvolysis in the presence of nucleophiles yield azoles with a variety of a-substituents.