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Three-component coupling reactions of isoquinolines, dimethyl acetylenedicarboxylate and indoles: a facile synthesis of 3-indolyl-1,2-dihydro-2-isoquinolinyl-2-butenedioate

โœ Scribed by J.S. Yadav; B.V. Subba Reddy; Nagendra Nath Yadav; Manoj K. Gupta


Book ID
108284890
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
165 KB
Volume
49
Category
Article
ISSN
0040-4039

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The reaction of isoquinoline and dimethy
โœ Vijay Nair; A.R Sreekanth; A.T Biju; Nigam P Rath ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 221 KB

The 1,4-dipolar intermediate generated by the addition of isoquinoline to dimethyl acetylenedicarboxylate is trapped by 1,2-and 1,4-benzoquinones to afford spiro[1,3]oxazino[2,3-a]isoquinoline derivatives in high yields.