Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine
β Scribed by Mitchell, Douglas A; Marletta, Michael A
- Book ID
- 109914025
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 235 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1552-4450
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π SIMILAR VOLUMES
## Abstract Thioredoxin superfamily members share a considerable degree of structural similarity, with a conserved CX~i~X~j~C motif at the active site, where C stand for two cysteines that alternate between a reduced thiol and oxidized disulfide states, and X~i~and X~j~ are two amino acids differen
## Abstract Caspases are cysteine proteases that play a critical role in the initiation and regulation of apoptosis. These enzymes act in a cascade to promote cell death through proteolytic cleavage of intracellular proteins. Since activation of apoptosis is implicated in human diseases such as can