Daily 6-mercaptopurine (6MP) forms the backbone of continuing chemotherapy for childhood lymphoblastic leukaemia (ALL). A major metabolic route is catalysed by thiopurine methyltransferase (TPMT). TPMT deficiency occurs in 1 in 300 individuals and results in high concentrations of thioguanine nucleo
✦ LIBER ✦
Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects
✍ Scribed by Connie Brouwer; Ronney A. De Abreu; Jenneke J. Keizer-Garritsen; Lambert H.J. Lambooy; Kai Ament; Patricia G.J.H. ter Riet; Elisabeth R. van Wering; Frans J.M. Trijbels; Anjo J.P. Veerman; Peter M. Hoogerbrugge; Jos P.M. Bökkerink
- Book ID
- 116428408
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 234 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0959-8049
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