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Thiopurine methyltransferase biochemical genetics: Human lymphocyte activity

✍ Scribed by Jon A. Loon; Richard M. Weinshilboum

Book ID
104783713
Publisher
Springer
Year
1982
Tongue
English
Weight
988 KB
Volume
20
Category
Article
ISSN
0006-2928

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Thiopurine methyltransferase (TPMT) catalyzes thiopurine S-methylation, an important metabolic pathway for drugs such as 6-mercaptopurine (6-MP). Inherited differences in the activity of this enzyme are related to individual differences in the therapeutic efficacy and toxicity of 6-MP and other thio