Thiophenesulfonamides as endothelin receptor antagonists

✍ Scribed by B. Raju; Chengde Wu; Adam Kois; Erik Verner; Ilya Okun; Fiona Stavros; Ming Fai Chan

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 353 KB
• Volume: 6
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(96)00496-9

✦ Synopsis

The synthesis and in vitro binding affinities of a series of thiophenesulfonamides as ET A selective endothelin receptor antagonists is described. The most potent inhibitor displayed an IC50 of 43 nM and 3 ktM to ET A and ETB receptors, respectively.