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Thionucleoside disulfide cross-linked duplex DNA

✍ Scribed by Robert S. Coleman; Jason L. McCary; Ronelito J. Perez

Book ID: 104260652
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 254 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)80005-1

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✦ Synopsis

A strategy for covalent cross-linking of duplex oligonucleotides is described, and is based on a direct base-to-base disulfide bond formed by iodine oxidation of two appropriately positioned thionucleoside bases. Cross-link formation between 4-thio-2'-deoxyuridine and 6-thio-2'-deoxyinosine is demonstrated in three sequence contexts (3' to 3', 5' to 5', or opposed).

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