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Thioanalogues of N-1-methylanabasine and nicotine – Synthesis and structure

✍ Scribed by Marzena Wojciechowska-Nowak; Władysław Boczoń; Beata Warżajtis; Urszula Rychlewska; Beata Jasiewicz


Book ID
108213364
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
934 KB
Volume
989
Category
Article
ISSN
0022-2860

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Coniine-15N was obtained by the reductive amination of 5-0x0octanal using sodium cyanoborohydride and a m m o n i ~m -~~N bromide. Nornicotine-l'-15N resulted from a similar reductive aminution of 4-oxo-4-(3'-pyridyl)butanal. Merhybtion with formaldehyde and ,formic acid afforded n i ~o t i n e -I '

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✍ Giang Vo-Thanh; François-Xavier Felpin; Gilbert Nourrisson; Michel Trierweiler; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 103 KB 👁 1 views

## Abstract The synthesis of ^15^N‐labelled nornicotine **2** and ^15^N‐labelled nicotine **1** is described via the reductive aminocyclization of a 1,4‐ketoaldehyde with a corresponding amine in the presence of sodium cyanoborohydride. Yields of 30% and 26%, respectively, were obtained from 3‐brom