Thioanalogues of N-1-methylanabasine and nicotine – Synthesis and structure
✍ Scribed by Marzena Wojciechowska-Nowak; Władysław Boczoń; Beata Warżajtis; Urszula Rychlewska; Beata Jasiewicz
- Book ID
- 108213364
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 934 KB
- Volume
- 989
- Category
- Article
- ISSN
- 0022-2860
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📜 SIMILAR VOLUMES
Coniine-15N was obtained by the reductive amination of 5-0x0octanal using sodium cyanoborohydride and a m m o n i ~m -~~N bromide. Nornicotine-l'-15N resulted from a similar reductive aminution of 4-oxo-4-(3'-pyridyl)butanal. Merhybtion with formaldehyde and ,formic acid afforded n i ~o t i n e -I '
## Abstract The synthesis of ^15^N‐labelled nornicotine **2** and ^15^N‐labelled nicotine **1** is described via the reductive aminocyclization of a 1,4‐ketoaldehyde with a corresponding amine in the presence of sodium cyanoborohydride. Yields of 30% and 26%, respectively, were obtained from 3‐brom