Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment
β Scribed by Margaret E McLaughlin; Tyler Jacks
- Book ID
- 114413188
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 167 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1535-6108
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## Abstract Neurofibromas are benign tumors of peripheral nerve that occur sporadically or in patients with the autosomal dominant tumor predisposition syndrome neurofibromatosis type 1 (NF1). Multiple neurofibroma subtypes exist which differ in their site of occurrence, their association with NF1,
Background. Patients with neurofibromatosis type 1 (NF1) are at increased risk for developing malignant neural crest tumors and juvenile myeloid leukemia. Although the normal allele of the NFZ tumor-suppressor gene is frequently deleted in some of the malignant tumors that arise in patients with NF1