Thin-layer chromatography and IR spectrophotometry of commercial sodium sulfobromophthalein solutions

✍ Scribed by F. Barbier; G. A. Deweerdt

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: English
• Weight: 577 KB
• Volume: 57
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600570521

✦ Synopsis

determined by their ability to maintain their position on a rotating rod.

( d ) The most pronounced prolongation of hexobarbital sleep time in mice was produced by GPIB. Less impressive, but nonetheless significant, was the sleep potentiating effect of APIM. In equimolar concentrations neither PIA nor BPIP exhibited any influence on barbiturate depression.

( e ) At comparatively high doses, the aldehydes were frequently observed to produce lacrimation, salivation, and flushing of the paw pads and ears, observations that prompted examination of the drugs for possible cholinomimetic activities.

(f) The estimated order of decreasing activity as lacrimatory stimulants in rats was APIM, BPIP (PIA), GPIB. This action was blocked by atropine prernedication.

(g) None of the aldehydes provoked chromodacryorrhea in rats.

( h ) PIA and BPIP and GPIB evoked short-lived tonic contractions in isolated guinea pig ileum that could be blocked by atropine. APIM produced only mild gut relaxation. There appears to be little relationship between the aldehydes' spasmogenic properties and their ability to stimulate lacrimation.

(3) Sollmann, T., " A Manual of Pharmacology," 8th ed..